For Providers

Lonu Joint & Muscle Support - An Evidence-Based Solution for your Patient with Arthritis

At Lonu, we are committed to delivering evidence-based, natural solutions for optimal joint health and wellness. Lonu Joint & Muscle Support has been developed based on clinical trials on rheumatoid arthritis and osteoarthritis in order to provide effective and safe doses of each ingredient for optimal potency, which makes it a great natural addition to your treatment plan.

Discover the Evidence Behind Each Ingredient in Lonu

Turmeric/Curcumin

  • Efficacy in RA*:  Multiple clinical trials have shown that turmeric curcumin can significantly reduce joint pain and inflammation in rheumatoid arthritis patients, improving quality of life and mobility.

  • The Evidence: A double-blind placebo-controlled RCT found that 500-1000mg/day of curcumin significantly improved ESR, CRP, RF, and disease activity compared to placebo [Read the article]

  • Reduced pain in OA*: Clinical trials indicate that curcumin effectively alleviates symptoms of osteoarthritis, particularly in reducing knee pain and improving joint function.

  • The Evidence: An RCT in 2021 demonstrated that daily supplementation of curcumin 1000mg/day significantly reduced knee OA pain and enhanced daily function  [Read the article] 

Quercetin

  • Symptom Management in RA*: Known for its anti-inflammatory properties, quercetin has been shown to effectively manage inflammation and reduce pain in rheumatoid arthritis.

  • The Evidence: A double-blind RCT showed that 500mg/day of quercetin significantly decreased joint pain, TNF levels, and disease activity in RA. [Read the article]

Pomegranate Extract

  • Rheumatoid Arthritis Relief*: Pomegranate extract has been found to decrease serum oxidative stress and inflammation markers in RA, and reduce disease activity.

  • The Evidence: An RCT in 2017 showed that 500/mg of pomegranate extract for 8 weeks showed a statistically significant reduction in inflammatory markers, oxidative stress, and disease activity in patients with RA.  [Read the article]

Coenzyme Q10 (CoQ10)

  • Inflammatory Reduction in RA*: CoQ10 has demonstrated potential in lowering inflammation in RA patients, suggesting benefits in pain management and joint health.

  • The Evidence:  A double-blind RCT in 2019 reported that CoQ10 supplementation showed a reduction in disease activity and ESR in patients with RA. [Read the article]

Why Choose Lonu?

  • Clinically Backed

    Every ingredient in Lonu is meticulously selected based on clinical trials to ensure efficacy and safety for your patients.

  • Holistic Approach

    Our formulations are designed to complement existing medical treatments, offering a holistic approach to arthritis management

  • High-Quality Standards

    Produced in FDA-approved facilities, Lonu meets the highest standards of product quality and safety.

 Ready to Enhance Your Patients’ Quality of Life?

Consider how Lonu can be part of your treatment plan for arthritis management. Provide your patients with a natural, effective option for relieving arthritis symptoms.

Articles

Amalraj, A., Varma, K., Jacob, J., Divya, C., Kunnumakkara, A. B., Stohs, S. J., & Gopi, S. (2017). A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study. Journal of medicinal food, 20(10), 1022–1030. https://doi.org/10.1089/jmf.2017.3930

Chandran, B., & Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy research : PTR, 26(11), 1719–1725. https://doi.org/10.1002/ptr.4639

Pourhabibi-Zarandi, F., Rafraf, M., Zayeni, H., Asghari-Jafarabadi, M., & Ebrahimi, A. A. (2022). Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. Phytotherapy research : PTR, 36(4), 1797–1806. https://doi.org/10.1002/ptr.7422

Khan, M. K., Khan, I. A., & Liaquat, A. (2022). Therapeutic Potential of Curcumin with and without Strengthening Exercises in Improving Rheumatoid Arthritis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 32(12), 1640–1643. https://doi.org/10.29271/jcpsp.2022.12.1640

Ebrahimzadeh, A., Abbasi, F., Ebrahimzadeh, A., Jibril, A. T., & Milajerdi, A. (2021). Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis. Complementary therapies in medicine, 61, 102773. https://doi.org/10.1016/j.ctim.2021.102773

Zeng, L., Yang, T., Yang, K., Yu, G., Li, J., Xiang, W., & Chen, H. (2022). Efficacy and Safety of Curcumin and Curcuma longaExtract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial. Frontiers in immunology, 13, 891822. https://doi.org/10.3389/fimmu.2022.891822

Lopresti, A. L., Smith, S. J., Jackson-Michel, S., & Fairchild, T. (2021). An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study. Nutrients, 14(1), 41. https://doi.org/10.3390/nu14010041

Wang, Z., Jones, G., Winzenberg, T., Cai, G., Laslett, L. L., Aitken, D., Hopper, I., Singh, A., Jones, R., Fripp, J., Ding, C., & Antony, B. (2020). Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Annals of internal medicine, 173(11), 861–869. https://doi.org/10.7326/M20-099

Panahi, Y., Alishiri, G. H., Parvin, S., & Sahebkar, A. (2016). Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. Journal of dietary supplements, 13(2), 209–220. https://doi.org/10.3109/19390211.2015.100861

Shep, D., Khanwelkar, C., Gade, P., & Karad, S. (2020). Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial. Medicine, 99(16), e19723. https://doi.org/10.1097/MD.0000000000019723

Srivastava, S., Saksena, A. K., Khattri, S., Kumar, S., & Dagur, R. S. (2016). Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology, 24(6), 377–388. https://doi.org/10.1007/s10787-016-0289-9

Liu, X., Tao, T., Yao, H., Zheng, H., Wang, F., & Gao, Y. (2023). Mechanism of action of quercetin in rheumatoid arthritis models: meta-analysis and systematic review of animal studies. Inflammopharmacology, 31(4), 1629–1645. https://doi.org/10.1007/s10787-023-01196-y

Javadi, F., Ahmadzadeh, A., Eghtesadi, S., Aryaeian, N., Zabihiyeganeh, M., Rahimi Foroushani, A., & Jazayeri, S. (2017). The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. Journal of the American College of Nutrition, 36(1), 9–15. https://doi.org/10.1080/07315724.2016.114009

Hu, Y., Gui, Z., Zhou, Y., Xia, L., Lin, K., & Xu, Y. (2019). Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free radical biology & medicine, 145, 146–160. https://doi.org/10.1016/j.freeradbiomed.2019.09.024

Yamaura, K., Nelson, A. L., Nishimura, H., Rutledge, J. C., Ravuri, S. K., Bahney, C., Philippon, M. J., & Huard, J. (2023). Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies. Ageing research reviews, 90, 101989. https://doi.org/10.1016/j.arr.2023.101989

Balbir-Gurman, A., Fuhrman, B., Braun-Moscovici, Y., Markovits, D., & Aviram, M. (2011). Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis: a pilot study. The Israel Medical Association journal : IMAJ, 13(8), 474–479.

Ghavipour, M., Sotoudeh, G., Tavakoli, E., Mowla, K., Hasanzadeh, J., & Mazloom, Z. (2017). Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients. European journal of clinical nutrition, 71(1), 92–96. https://doi.org/10.1038/ejcn.2016.151

Abdollahzad, H., Aghdashi, M. A., Asghari Jafarabadi, M., & Alipour, B. (2015). Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Archives of medical research, 46(7), 527–533. https://pubmed.ncbi.nlm.nih.gov/26342738/

Lee, J., Hong, Y. S., Jeong, J. H., Yang, E. J., Jhun, J. Y., Park, M. K., Jung, Y. O., Min, J. K., Kim, H. Y., Park, S. H., & Cho, M. L. (2013). Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PloS one, 8(7), e69362. https://doi.org/10.1371/journal.pone.0069362

Nachvak, S. M., Alipour, B., Mahdavi, A. M., Aghdashi, M. A., Abdollahzad, H., Pasdar, Y., Samadi, M., & Mostafai, R. (2019). Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Clinical rheumatology, 38(12), 3367–3374. https://doi.org/10.1007/s10067-019-04723-x

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.